miR-302/367 is the most abundant miRNA cluster in human embryonic stem cells (hESCs) and can promote somatic cell reprogramming.However, its role in hESCs remains poorly understood.Here, we studied functional roles of the endogenous miR-302/367 cluster in hESCs by employing specific TALE-based transcriptional repressors.We revealed that miR-302/367
Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis
Objectives Methotrexate (MTX) is currently the Sanitation Pails recommended first-line therapy for treating psoriatic arthritis (PsA), despite lacking clear evidence.No estimates of efficacy of MTX in usual care and no clear MTX responsive clinical or laboratory variables are currently available.This study describes the response to MTX monotherapy
Effect of tomato post-harvest fungicide treatment and storage conditions on the quality of fruits, and biological value of tomato pulp and concentrated pulp
The influence of storage conditions on the quality of tomato fruits was tested.The rate of ripening was established in normal air, where tomatoes ripen quickly, under controlled atmosphere where they ripen more slowly and under low pressure, where they ripen slowest.The influence of post-harvest benomyl or methylthiophanate treatment on TOOTHPASTE
On word order and non-conservative percentage quantification in Slavic and German
This paper discusses conservative and non-conservative construals of percentage quantifiers (%Qs), e.g., 50% of the women vs.50% women, in Slavic and German.Based on data from corpora and cross-linguistic questionnaires, we make the novel empirical generalization that word order plays a crucial role in distinguishing between these two readings, irr